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content:benign_familial_neonatal_epilepsy [2020/02/15 16:35] – [Electroencephalography] icna | content:benign_familial_neonatal_epilepsy [2020/02/15 17:54] – [Electroencephalography] icna | ||
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====== Benign familial neonatal epilepsy ====== | ====== Benign familial neonatal epilepsy ====== | ||
Benign familial neonatal epilepsy is a rare autosomal dominant epileptic syndrome characterised by frequent brief seizures within the first days of life. | Benign familial neonatal epilepsy is a rare autosomal dominant epileptic syndrome characterised by frequent brief seizures within the first days of life. | ||
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===== Clinical features ===== | ===== Clinical features ===== | ||
* Seizures mainly occur in full-term normal neonates following a normal pregnancy and delivery and without precipitating factors. Seizures are brief, of 1–2 min and may be as frequent as 20–30 per day. | * Seizures mainly occur in full-term normal neonates following a normal pregnancy and delivery and without precipitating factors. Seizures are brief, of 1–2 min and may be as frequent as 20–30 per day. | ||
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* The neonate is asymptomatic interictally | * The neonate is asymptomatic interictally | ||
* Pure clonic or focal seizures are rarely seen[(: | * Pure clonic or focal seizures are rarely seen[(: | ||
+ | ===== Electroencephalography ===== | ||
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- | ===== Electroencephalography ===== | + | |
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* The apnoea and tonic motor activity corresponds to synchronous and bilateral flattening of 5–19s on the ictal EEG | * The apnoea and tonic motor activity corresponds to synchronous and bilateral flattening of 5–19s on the ictal EEG | ||
* followed by bilateral and often asymmetrical discharges of spikes and sharp waves with a duration of 1–2 min, coinciding with the vocalisations, | * followed by bilateral and often asymmetrical discharges of spikes and sharp waves with a duration of 1–2 min, coinciding with the vocalisations, |