content:benign_familial_neonatal_epilepsy

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content:benign_familial_neonatal_epilepsy [2020/02/15 16:31] – [Differential diagnosis] icnacontent:benign_familial_neonatal_epilepsy [2020/02/23 20:32] – icna
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 ====== Benign familial neonatal epilepsy ====== ====== Benign familial neonatal epilepsy ======
 Benign familial neonatal epilepsy is a rare autosomal dominant epileptic syndrome characterised by frequent brief seizures within the first days of life. Benign familial neonatal epilepsy is a rare autosomal dominant epileptic syndrome characterised by frequent brief seizures within the first days of life.
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 ===== Clinical features ===== ===== Clinical features =====
   * Seizures mainly occur in full-term normal neonates following a normal pregnancy and delivery and without precipitating factors. Seizures are brief, of 1–2 min and may be as frequent as 20–30 per day.   * Seizures mainly occur in full-term normal neonates following a normal pregnancy and delivery and without precipitating factors. Seizures are brief, of 1–2 min and may be as frequent as 20–30 per day.
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   * The neonate is asymptomatic interictally   * The neonate is asymptomatic interictally
   * Pure clonic or focal seizures are rarely seen[(:cite:panayiotopoulos2005)]   * Pure clonic or focal seizures are rarely seen[(:cite:panayiotopoulos2005)]
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 ===== Electroencephalography ===== ===== Electroencephalography =====
-[{{ :content:theta-point-alternans.jpg?400|theta pointu alternant(source: Plouin 1992)}}] +<WRAP right> 
-  * The inter-ictal EEG may be normal, discontinuous, have focal or multifocal abnormalities or have a [[theta pointu alternant pattern]][(:cite:6660252>{{pubmed>long:6660252}})+<figure fig1> 
 +{{ :content:theta-point-alternans.jpg?400|theta pointu alternant}} 
 +<caption>theta pointu alternant (//source: Plouin et al(1992)//[(:cite:6660252)]</caption> 
 +</figure> 
 +</WRAP> 
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 +  * The inter-ictal EEG may be normal, discontinuous, have focal or multifocal abnormalities or have a [[theta pointu alternant pattern]]
   * The apnoea and tonic motor activity corresponds to synchronous and bilateral flattening of 5–19s on the ictal EEG   * The apnoea and tonic motor activity corresponds to synchronous and bilateral flattening of 5–19s on the ictal EEG
   * followed by bilateral and often asymmetrical discharges of spikes and sharp waves with a duration of 1–2 min, coinciding with the vocalisations, chewing and focal or generalised clonic activity.76,77   * followed by bilateral and often asymmetrical discharges of spikes and sharp waves with a duration of 1–2 min, coinciding with the vocalisations, chewing and focal or generalised clonic activity.76,77
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 ===== References ===== ===== References =====
 ~~REFNOTES~~ ~~REFNOTES~~
 +{{tag>neonatal_seizures}}
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