content:alpha-feto_protein_serum

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content:alpha-feto_protein_serum [2020/02/17 19:42] – [Alpha-Feto protein, serum] icnacontent:alpha-feto_protein_serum [2022/04/30 11:54] (current) – changed pubmed syntax administrator@icnapedia.org
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   * **Classic Ataxia Telangiectasia**   * **Classic Ataxia Telangiectasia**
     * Infancy/childhood     * Infancy/childhood
-    * ↑ AFP levels 100–900 μg/l. Rarely in <1% normal values are seen[(:cite:19535770>{{pubmed>short:19535770}})]+    * ↑ AFP levels 100–900 μg/l. Rarely in <1% normal values are seen[(:cite:19535770>{{pmid>long:19535770}})]
     * in Variant A-T (ATM) AFP levels are 50–500 μg/l     * in Variant A-T (ATM) AFP levels are 50–500 μg/l
     * other laboratory markers include immunoglobulins, liver transaminases, chromosomal rearrangements, increased radiosensitivity     * other laboratory markers include immunoglobulins, liver transaminases, chromosomal rearrangements, increased radiosensitivity
   * **Ataxia with Oculomotor Apraxia Type 1 (AOA1)**   * **Ataxia with Oculomotor Apraxia Type 1 (AOA1)**
     * AOA1 (APTX)     * AOA1 (APTX)
-      *AFP 10-20 μg/l. ↑ AFP seen only in exceptional cases[(:cite:24120489>{{pubmed>short:24120489}})]. +      *AFP 10-20 μg/l. ↑ AFP seen only in exceptional cases[(:cite:24120489>{{pmid>long:24120489}})]. 
     * AOA2 (SETX)     * AOA2 (SETX)
       * Adolescence/adulthood       * Adolescence/adulthood
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     * raised serum/csf lactate     * raised serum/csf lactate
  
-CSF AFP levels in normal infants also decline with gestational age in proportion to levels of AFP in serum[(:cite:PMID10612715>{{pubmed>short:10612715}})][(:cite:15802029>{{pubmed>short:15802029}})].+CSF AFP levels in normal infants also decline with gestational age in proportion to levels of AFP in serum[(:cite:PMID10612715>{{pmid>long:10612715}})][(:cite:15802029>{{pmid>long:15802029}})].
   * median 61 kIU/L (5th-95th centile: 2-889 kIU/L) in infants -69 to 31 days old   * median 61 kIU/L (5th-95th centile: 2-889 kIU/L) in infants -69 to 31 days old
   * median 1.2 kIU/L (5th-95th centile: 0.1-12.5 kIU/L) in infants 32 to 110 days old   * median 1.2 kIU/L (5th-95th centile: 0.1-12.5 kIU/L) in infants 32 to 110 days old
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