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content:alpha-feto_protein_serum [2020/02/16 20:54] – icna | content:alpha-feto_protein_serum [2022/04/30 11:54] (current) – changed pubmed syntax administrator@icnapedia.org | ||
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====== Alpha-Feto protein, serum ====== | ====== Alpha-Feto protein, serum ====== | ||
- | <alert type=" | ||
{{tag> | {{tag> | ||
==== Indications ==== | ==== Indications ==== | ||
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* **Classic Ataxia Telangiectasia** | * **Classic Ataxia Telangiectasia** | ||
* Infancy/ | * Infancy/ | ||
- | * ↑ AFP levels 100–900 μg/l. Rarely in <1% normal values are seen[(: | + | * ↑ AFP levels 100–900 μg/l. Rarely in <1% normal values are seen[(: |
* in Variant A-T (ATM) AFP levels are 50–500 μg/l | * in Variant A-T (ATM) AFP levels are 50–500 μg/l | ||
* other laboratory markers include immunoglobulins, | * other laboratory markers include immunoglobulins, | ||
* **Ataxia with Oculomotor Apraxia Type 1 (AOA1)** | * **Ataxia with Oculomotor Apraxia Type 1 (AOA1)** | ||
* AOA1 (APTX) | * AOA1 (APTX) | ||
- | *AFP 10-20 μg/l. ↑ AFP seen only in exceptional cases[(: | + | *AFP 10-20 μg/l. ↑ AFP seen only in exceptional cases[(: |
* AOA2 (SETX) | * AOA2 (SETX) | ||
* Adolescence/ | * Adolescence/ | ||
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* raised serum/csf lactate | * raised serum/csf lactate | ||
- | CSF AFP levels in normal infants also decline with gestational age in proportion to levels of AFP in serum[(: | + | CSF AFP levels in normal infants also decline with gestational age in proportion to levels of AFP in serum[(: |
* median 61 kIU/L (5th-95th centile: 2-889 kIU/L) in infants -69 to 31 days old | * median 61 kIU/L (5th-95th centile: 2-889 kIU/L) in infants -69 to 31 days old | ||
* median 1.2 kIU/L (5th-95th centile: 0.1-12.5 kIU/L) in infants 32 to 110 days old | * median 1.2 kIU/L (5th-95th centile: 0.1-12.5 kIU/L) in infants 32 to 110 days old |