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content:alpha-feto_protein_serum [2020/02/16 20:46] – icna | content:alpha-feto_protein_serum [2020/02/16 20:53] – icna | ||
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* any type of movement disorder in early childhood, cerebellar ataxias, [[oculomotor apraxia]](saccadic impairment) | * any type of movement disorder in early childhood, cerebellar ataxias, [[oculomotor apraxia]](saccadic impairment) | ||
==== Notes ==== | ==== Notes ==== | ||
- | Alpha-fetoprotein (AFP) is present in fetal serum in concentrations up to 5,000,000 μg/l Postnatally AFP gene expression is turned down with a subsequent fall of the serum concentrations to 'adult values' | + | Alpha-fetoprotein (AFP) is present in fetal serum in concentrations up to 5,000,000 μg/l. Postnatally |
- | Increased serum AFP is a biomarker for [[Ataxia Telangiectasia]], | + | Increased serum AFP is a biomarker for [[Ataxia Telangiectasia]], |
+ | |||
+ | CSF AFP levels in normal infants also decline with gestational age in proportion to levels of AFP in serum[(: | ||
+ | * median 61 kIU/L (5th-95th centile: 2-889 kIU/L) in infants -69 to 31 days old | ||
+ | * median 1.2 kIU/L (5th-95th centile: 0.1-12.5 kIU/L) in infants 32 to 110 days old | ||
* **Classic Ataxia Telangiectasia** | * **Classic Ataxia Telangiectasia** |