content:acycarnitines

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content:acycarnitines [2020/02/16 17:53] – icnacontent:acycarnitines [2020/02/16 17:57] – [Notes] icna
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 suspected fatty acid oxidation disorders, acute myopathy, rhabdomyolysis, unexplained increased creatine kinase suspected fatty acid oxidation disorders, acute myopathy, rhabdomyolysis, unexplained increased creatine kinase
 ==== Notes ==== ==== Notes ====
-  * Diagnostic results are usually characterized by a pattern of significantly elevated acylcarnitine species compared to normal and disease controls.+  * diagnostic results are usually characterized by a pattern of significantly elevated acylcarnitine species compared to normal and disease controls.
   * serum acylcarnitines are useful in the diagnosis of fatty acid oxidation disorders and several organic acidurias   * serum acylcarnitines are useful in the diagnosis of fatty acid oxidation disorders and several organic acidurias
   * serum acylcarnitines also useful in evaluating treatment during follow-up of patients with fatty acid beta-oxidation disorders and several organic acidurias   * serum acylcarnitines also useful in evaluating treatment during follow-up of patients with fatty acid beta-oxidation disorders and several organic acidurias
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 ==== Reference values ==== ==== Reference values ====
-<table label> +<table refvalues> 
-<caption>caption</caption> +^                                      ^ 8 days-7 years  ^ > or =8 years  |             | 
- 8 days-7 years > or =8 years  +| < or =7 days (nmol/mL)               | (nmol/mL)       | (nmol/mL)      |             | 
-< or =7 days (nmol/mL) (nmol/mL) (nmol/mL)  +| Acetylcarnitine, C2                  | 2.14-15.89      | 2.00-27.57     | 2.00-17.83  | 
-Acetylcarnitine, C2 2.14-15.89 2.00-27.57 2.00-17.83 +| Acrylylcarnitine, C3:1               | <0.04           | <0.05          | <0.07       | 
-Acrylylcarnitine, C3:1 <0.04 <0.05 <0.07 +| Propionylcarnitine, C3               | <0.55           | <1.78          | <0.88       | 
-Propionylcarnitine, C3 <0.55 <1.78 <0.88 +| Formiminoglutamate, FIGLU            | <0.43           | <0.08          | <0.14       | 
-Formiminoglutamate, FIGLU <0.43 <0.08 <0.14 +| Iso-/Butyrylcarnitine, C4            | <0.46           | <1.06          | <0.83       | 
-Iso-/Butyrylcarnitine, C4 <0.46 <1.06 <0.83 +| Tiglylcarnitine, C5:1                | <0.05           | <0.09          | <0.11       | 
-Tiglylcarnitine, C5:1 <0.05 <0.09 <0.11 +| Isovaleryl-/2-Methylbutyrylcarn C5   | <0.38           | <0.63          | <0.51       | 
-Isovaleryl-/2-Methylbutyrylcarn C5 <0.38 <0.63 <0.51 +| 3-OH-iso-/butyrylcarnitine, C4-OH    | <0.13           | <0.51          | <0.18       | 
-3-OH-iso-/butyrylcarnitine, C4-OH <0.13 <0.51 <0.18 +| Hexenoylcarnitine, C6:1              | <0.12           | <0.10          | <0.15       | 
-Hexenoylcarnitine, C6:1 <0.12 <0.10 <0.15 +| Hexanoylcarnitine, C6                | <0.14           | <0.23          | <0.17       | 
-Hexanoylcarnitine, C6 <0.14 <0.23 <0.17 +| 3-OH-isovalerylcarnitine, C5-OH      | <0.08           | <0.12          | <0.10       | 
-3-OH-isovalerylcarnitine, C5-OH <0.08 <0.12 <0.10 +| Benzoylcarnitine                     | <0.13           | <0.07          | <0.10       | 
-Benzoylcarnitine <0.13 <0.07 <0.10 +| Heptanoylcarnitine, C7               | <0.05           | <0.05          | <0.06       | 
-Heptanoylcarnitine, C7 <0.05 <0.05 <0.06 +| 3-OH-hexanoylcarnitine, C6-OH        | <0.08           | <0.19          | <0.09       | 
-3-OH-hexanoylcarnitine, C6-OH <0.08 <0.19 <0.09 +| Phenylacetylcarnitine                | <0.15           | <0.22          | <0.29       | 
-Phenylacetylcarnitine <0.15 <0.22 <0.29 +| Salicylcarnitine                     | <0.08           | <0.09          | <0.09       | 
-Salicylcarnitine <0.08 <0.09 <0.09 +| Octenoylcarnitine, C8:1              | <0.48           | <0.91          | <0.88       | 
-Octenoylcarnitine, C8:1 <0.48 <0.91 <0.88 +| Octanoylcarnitine, C8                | <0.19           | <0.45          | <0.78       | 
-Octanoylcarnitine, C8 <0.19 <0.45 <0.78 +| Malonylcarnitine, C3-DC              | <0.09           | <0.14          | <0.26       | 
-Malonylcarnitine, C3-DC <0.09 <0.14 <0.26 +| Decadienoylcarnitine, C10:2          | <0.11           | <0.12          | <0.26       | 
-Decadienoylcarnitine, C10:2 <0.11 <0.12 <0.26 +| Decenoylcarnitine, C10:1             | <0.25           | <0.46          | <0.47       | 
-Decenoylcarnitine, C10:1 <0.25 <0.46 <0.47 +| Decanoylcarnitine, C10               | <0.27           | <0.91          | <0.88       | 
-Decanoylcarnitine, C10 <0.27 <0.91 <0.88 +| Methylmalonyl-/succinylcarn, C4-DC   | <0.05           | <0.05          | <0.05       | 
-Methylmalonyl-/succinylcarn, C4-DC <0.05 <0.05 <0.05 +| 3-OH-decenoylcarnitine, C10:1-OH     | <0.12           | <0.12          | <0.13       | 
-3-OH-decenoylcarnitine, C10:1-OH <0.12 <0.12 <0.13 +| Glutarylcarnitine, C5-DC             | <0.06           | <0.10          | <0.11       | 
-Glutarylcarnitine, C5-DC <0.06 <0.10 <0.11 +| Dodecenoylcarnitine, C12:1           | <0.19           | <0.37          | <0.35       | 
-Dodecenoylcarnitine, C12:1 <0.19 <0.37 <0.35 +| Dodecanoylcarnitine, C12             | <0.18           | <0.35          | <0.26       | 
-Dodecanoylcarnitine, C12 <0.18 <0.35 <0.26 +| 3-Methylglutarylcarnitine, C6-DC     | <0.28           | <0.21          | <0.43       | 
-3-Methylglutarylcarnitine, C6-DC <0.28 <0.21 <0.43 +| 3-OH-dodecenoylcarnitine, C12:1-OH   | <0.11           | <0.10          | <0.13       | 
-3-OH-dodecenoylcarnitine, C12:1-OH <0.11 <0.10 <0.13 +| 3-OH-dodecanoylcarnitine, C12-OH     | <0.06           | <0.09          | <0.08       | 
-3-OH-dodecanoylcarnitine, C12-OH <0.06 <0.09 <0.08 +| Tetradecadienoylcarnitine, C14:2     | <0.09           | <0.13          | <0.18       | 
-Tetradecadienoylcarnitine, C14:2 <0.09 <0.13 <0.18 +| Tetradecenoylcarnitine, C14:1        | <0.16           | <0.35          | <0.24       | 
-Tetradecenoylcarnitine, C14:1 <0.16 <0.35 <0.24 +| Tetradecanoylcarnitine, C14          | <0.11           | <0.15          | <0.12       | 
-Tetradecanoylcarnitine, C14 <0.11 <0.15 <0.12 +| Octanedioylcarnitine, C8-DC          | <0.25           | <0.19          | <0.19       | 
-Octanedioylcarnitine, C8-DC <0.25 <0.19 <0.19 +| 3-OH-tetradecenoylcarnitine C14:1OH  | <0.06           | <0.18          | <0.13       | 
-3-OH-tetradecenoylcarnitine C14:1OH <0.06 <0.18 <0.13 +| 3-OH-tetradecanoylcarnitine, C14-OH  | <0.04           | <0.05          | <0.08       | 
-3-OH-tetradecanoylcarnitine, C14-OH <0.04 <0.05 <0.08 +| Hexadecenoylcarnitine, C16:1         | <0.15           | <0.21          | <0.10       | 
-Hexadecenoylcarnitine, C16:1 <0.15 <0.21 <0.10 +| Hexadecanoylcarnitine, C16           | <0.36           | <0.52          | <0.23       | 
-Hexadecanoylcarnitine, C16 <0.36 <0.52 <0.23 +| 3-OH-hexadecenoylcarnitine,C16:1-OH  | <0.78           | <0.36          | <0.06       | 
-3-OH-hexadecenoylcarnitine,C16:1-OH <0.78 <0.36 <0.06 +| 3-OH-hexadecanoylcarnitine, C16-OH   | <0.10           | <0.07          | <0.06       | 
-3-OH-hexadecanoylcarnitine, C16-OH <0.10 <0.07 <0.06 +| Octadecadienoylcarnitine, C18:2      | <0.12           | <0.31          | <0.24       | 
-Octadecadienoylcarnitine, C18:2 <0.12 <0.31 <0.24 +| Octadecenoylcarnitine, C18:1         | <0.25           | <0.45          | <0.39       | 
-Octadecenoylcarnitine, C18:1 <0.25 <0.45 <0.39 +| Octadecanoylcarnitine, C18           | <0.10           | <0.12          | <0.14       | 
-Octadecanoylcarnitine, C18 <0.10 <0.12 <0.14 +| Dodecanedioylcarnitine, C12-DC       | <0.10           | <0.04          | <0.04       | 
-Dodecanedioylcarnitine, C12-DC <0.10 <0.04 <0.04 +| 3-OH-octadecadienoylcarn, C18:2-OH   | <0.04           | <0.06          | <0.06       | 
-3-OH-octadecadienoylcarn, C18:2-OH <0.04 <0.06 <0.06 +| 3-OH-octadecenoylcarnitine C18:1-OH  | <0.03           | <0.04          | <0.06       | 
-3-OH-octadecenoylcarnitine C18:1-OH <0.03 <0.04 <0.06 +| 3-OH-octadecanoylcarnitine, C18-OH   | <0.03           | <0.05          | <0.03       | 
-3-OH-octadecanoylcarnitine, C18-OH <0.03 <0.05 <0.03+<caption>source: [[https://www.mayocliniclabs.com/test-catalog/Clinical+and+Interpretive/60644|Mayo Clinic Labs]]</caption>
 </table> </table>
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