rare autosomal recessive genetic disorder.
characterized by severe intellectual disability, microcephaly, hypothalamic hypogonadism
associated with mutations in at least four different genes, RAB18, RAB3GAP1, RAB3GAP2, or TCB1D20
in 1993 Warburg used the term MICRO syndrome to describe an autosomal recessive syndrome comprising microcephaly, microcornea, congenital Cataract, mental retardation, optic atrophy, and hypogenitalism
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