alias: Multifocal acquired demyelinating sensory and motor neuropathy (MADSAM)
Prevalence: 1-9 / 1 000 000
Age of onset: Variable
Inheritance: Sporadic
Lewis-Sumner syndrome (LSS) is a rare acquired demyelinating polyneuropathy characterized by asymmetrical distal weakness of the upper or lower extremities and motor dysfunction with adult onset. It is considered to be a variant of chronic inflammatory demyelinating polyneuropathy