Benign familial neonatal epilepsy is a rare autosomal dominant epileptic syndrome characterised by frequent brief seizures within the first days of life.
Benign (non-familial) neonatal seizures | Benign familial neonatal seizures | |
---|---|---|
Main seizures | Mostly clonic | Tonic-clonic |
Onset | Fifth day of life | Second or third day of life |
Duration of seizures | Status epilepticus (median 20 hours) | Repetitive isolated seizures |
Main causes | Unknown, probably environmental | Autosomal dominant |
Subsequent seizures | Practically nil (0.5%) | Relatively high (11%) |
Psychomotor deficits | Minor | Practically non-existent |
Ictal EEG | Usually localised spikes | Usually generalised flattening |
Interictal EEG | Usually theta pointu alternant | Normal or focal abnormalities |
Source: The Epilepsies: Seizures, Syndromes and Management. Panayiotopoulos CP. Oxfordshire (UK): Bladon Medical Publishing; 2005. |