====== Lennox-Gastaut syndrome and Doose syndrome ====== ^ Feature ^ Lennox-Gastaut Syndrome | Doose Syndrome | | | | | | Main seizures | Tonic; atonic and atypical absences | Myoclonic, atonic and myoclonic-atonic | | | | | | Tonic seizures | Common and characteristic, diurnal and nocturnal | Probably exclusion criterion (nocturnal tonic seizures are accepted by some authors) | | | | | | Tonic drop attacks | Common | Incompatible | | | | | | Atypical absences | Common also occurring independently of other seizures | Uncommon, they usually accompany myoclonic or atonic episodes | | | | | | Developmental abnormalities before onset of seizures | Common | Exceptional if any | | | | | | Aetiology | Symptomatic or possibly symptomatic (idiopathic cases are accepted by some authorities) | Idiopathic1 (although symptomatic or possibly symptomatic cases are included in the ILAE classification of 198912) | | | | | | Genetic predisposition | None | Common | | | | | | Development from West syndrome | Common | Incompatible | | | | | | EEG background | Abnormal by rule | Usually normal particularly at onset | | | | | | EEG episodic fast activity and rapid spikes | Common and often characteristic | Exceptional and mainly in sleep | | | | | | EEG slow generalised spike wave | Usually | Usually 2–3 Hz | | | | | | Prognosis | Commonly bad | Commonly relatively good | | | | |