====== Lewis Sumner syndrome ======
alias: [[Multifocal acquired demyelinating sensory and motor neuropathy]] (MADSAM)

**Prevalence:** 1-9 / 1 000 000

**Age of onset:** Variable

**Inheritance:** Sporadic

Lewis-Sumner syndrome (LSS) is a rare acquired demyelinating polyneuropathy characterized by asymmetrical distal weakness of the upper or lower extremities and motor dysfunction with adult onset. It is considered to be a variant of [[chronic inflammatory demyelinating polyneuropathy]]