Reference ranges for AED drug levels

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AED Reference Ranges

Drug Metabolite Units Ref. range Ref. range metabolite
Acetazolamide   mg/L 02-Dec  
Carbamazepine Carbamazepine 10-11 epoxide mg/L 1.5-9  
Carbamazepine (free)   mg/L 0.5-3  
Clobazam Desmethylclobazam mcg/L <200 <200
Clonazepam   mcg/L 25-85  
Desmethylmethsuximide   mg/L Oct-40  
Diazepam Nordiazepam mg/L <1.0 <1.5
Ethosuximide   mg/L 40-80  
Felbamate   mg/L 20-60  
Gabapentin   mg/L Feb-20  
Oxcarbazepine 10-hydroxy Carbamazepine mg/L   15-35
Lamotrigine   mg/L Jan-15  
Levetiracetam   mg/L Jun-20  
Nitrazepam   mcg/L 50-150  
Phenobarbital   mg/L May-30  
Phenytoin   mg/L Jul-20  
Phenytoin (free)   mg/L 0.7-2  
Pregabalin   mg/L *  
Primidone Phenobarbital mg/L <13 15-30
Stiripentol   mg/L *  
Sulthiame   mg/L 02-Dec  
Tiagabine   mcg/L 20-100  
Topiramate   mg/L May-20  
Valproate   mg/L 50-100  
Valproate (free)   mg/l 04-Nov  
Vigabatrin   mg/L May-35  
Zonisamide   mg/L 15-4-  

Source: Dr David Berry, Guys Hospital, London adapted from Epilepsy. Oxford Specialist Handbooks in Neurology 2009
APA Style
Reference ranges for AED drug levels. (n.d.). In ICNApedia. Retrieved August 23,2019 23:43:00 from
MLA Style
"Reference ranges for AED drug levels." ICNApedia: The Child Neurology Knowledge Environment, Inc. May 06, 2018. Web. August 23,2019 23:43:00
AMA Style
ICNApedia contributors. Reference ranges for AED drug levels. ICNApedia, The Child Neurology Knowledge Environment. May 06, 2018. Available at: August 23,2019 23:43:00.

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