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Handbook of Pediatric Electroencephalography by Veena Kander now on ICNApedia VLE

Neurolists

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Disease Enzyme Defect and Genetics Onset Early Manifestations Vision and Hearing Motor System Seizures Laboratory and Tissue Studies Course Adrenoleukodystrophy and variants (peroxisomal disease) X-linked Xq28 Neonatal form: AR Acyl-CoA synthetase 5–10 y May also present as newborn, adolescent, or adult Impaired intellect ...
 
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Disease Enzyme Defect and Genetics Onset Early Manifestations Vision and Hearing Somatic Findings Motor Findings Seizures Labs Clinical Course White matter Globoid (Krabbe) leukodystrophy Recessive galactocerebroside β-galactosidase deficiency. Chromosome 14q21–14q31 Infantile form first 6 mo. Late-onset form 2–6 y. Adolescent and adult forms are rare Feeding difficulties Shrill cry ...
 
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  Adverse Drug Reaction Acute Side Effects   Drug Concentration Dependent Idiosyncratic Chronic Side Effects Carbamazepine Diplopia Dizziness Drowsiness Nausea Unsteadiness Lethargy Blood dyscrasias Rash (HLA antigen testing may be relevant to avoid Stevens–Johnson or toxic epidermal necrolysis) ...
 
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Drug Brand Name Initial or Starting Dose Usual Range or Maximum Dose Comments Target Serum Concentration Range Barbiturates Phenobarbital Various 1-3 mg/kg/d (10-20 mg/kg LD) 180-300 mg 10-40 μg/mL (43-172 μmol/L) Primidone Mysoline 100-125 mg/d 750-2000 mg 5-10 μg/mL (23-46 μmol/L)...
 
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Benign (no-familial) neonatal seizures versus Benign familial neonatal seizures
 
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References Drug Study Design Evidence level Dose Age(years) Number of patients Responders (%) Active drug Responders (%) Placebo p value Hamalainen et al 1997 Ibuprofen RCT A 10 mg/kg 4–16 88 68 37...
 
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Choice Antiepileptic Drug (AED)medication in children    Seizure type/syndrome First Line Second Line Drugs to avoid Focal seizures CBZ,LTG,OXC,TPM,VPA CLB,GBP,LEV,PHT,TGB,ZON,PGN   Generalised Seizures          Absence ESM,LTG,VPA ...
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4th European Stroke Organisation Conference (ESOC 2018)