Building: Bourbon Cataratas Convention Centre, Foz do Iguaçu
Room: Iguazu I
Date: 2014-05-08 02:30 PM – 02:45 PM
Last modified: 2014-02-09
Abstract
BACKGROUND: Induced hypothermia has recently been introduced as one of the interventions used in management of neonates with intrapartum asphyxia at the institution. OBJECTIVE: To describe infant characteristics (demographics and cooling criteria), during induced hypothermia and outcomes to hospital discharge. METHOD: Retrospective record review of infants who had asphyxia and were managed with whole body cooling. Patients were cooled according to the modified TOBY criteria. On discharge all patients had a neurological examination. RESULTS: From October 2011 to April 2013, 52 patients had been cooled. The median birth weight and gestational age was 3149 grams and 39 weeks respectively. The median 5 minute Apgar score was 5 and 21% required resuscitation for >10 minutes. The mean pH was 7.021 and base deficit was 20.4 mmols/ L. Moderate and severe encephalopathy were noted in 79% and 19% patients before cooling respectively. Only 53% of patients had an aEEG performed before induced hypothermia (shortage of machines). None of the patients required mechanical ventilation except one who was put on nasal continuous positive airway pressure during cooling. Five patients died (9%) died before discharge. Among the survivors 18% were discharged with mild neurological abnormalities on examination and 28% had moderately abnormal neurological findings, 16 patients were not examined by the neurologist on discharge. Conclusion: Induced hypothermia is feasible within a resource poor setting. Resources remain a major factor in managing these patients according to the protocol. Short term results are promising but follow up of the patients is vital.
Keywords
References
Azzopardi DV, Strohm B, Edwards AD, et al. Moderate hypothermia
to treat perinatal asphyxial encephalopathy. N Engl J Med 2009;361:1349-58;
Edwards AD, Brocklehurst P, Gunn AJ, et al. Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data. BMJ 2010;340:363