Building: Bourbon Cataratas Convention Centre, Foz do Iguaçu
Room: Iguazu I
Date: 2014-05-08 03:00 PM – 03:15 PM
Last modified: 2014-02-09
Abstract
Introduction: Neonatal Arterial Ishemic Stroke (NAIS) causes significant long-term morbidity. Information on evolution of neurological deficits after acute NAIS is lacking.Objectives: To study the emergence and evolution of neurodeficits over time following acute NAIS.Methods: Retrospective analysis of neonates with acute AIS from 1999–2009 was conducted. Outcome was assessed by the validated Pediatric Stroke Outcome Measure (PSOM), administered prospectively during follow-up. PSOM scores between 3–6months, 6–12months, 1–3years, 3–5years and after 5-years were analyzed. Only patients with minimum 3 assessments, each during different time-interval, were analyzed. Within individual PSOM sphere, any neurodeficit was considered abnormal.Results: Fifty-two (27 males) of 87 acute NAIS were included. The table depicts our salient findings on interim analysis.
Neurological Deficits
Time interval following Stroke
3-6months (N=20)
6-12months
(N=21)
1-3years
(N=72)*
3-5years
(N=40)
>5years
(N=43)
Left-sensorimotor
45%
48%
44%
40%
35%
Right-sensorimotor
35%
24%
33%
20%
23%
Language comprehension
5%
10%
38%
38%
30%
Language expression
0
5%
18%
8%
23%
Cognitive/Behaviour
problems
0
0
15%
18%
42%
N= # neonates assessed, * some neonates had ≥ 2 asssessments
Sensorimotor and language deficits emerge over early infancy and between 1–3years respectively; these remain persistent in many thereafter. Cognitive/behavior problems surface in pre-schoolers and worsen during school age. Predictor testing is under way.
Conclusions: A distinct pattern of emergence and evolution of neurodeficits is evident following NAIS.This information can be helpful for timing of rehabilitation interventions.