HSE involvement commonly occurs in the regions of inferomedial temporal lobe, inferior frontal lobe and insular cortex (1).

We present a case of a meningoencephalitis with Corpus Striatum involvement that, to our knowledge, has not been reported in the literature previously, which was proved to be HSV-1 by PCR, and it can be considered as an atypical involvement for HSE.

CASE REPORT: A 17-month-old female patient was brought with complaints of fever, lethargy and seizures. Brain MRI findings were suggestive of encephalomalacia with cystic changes detected in bilateral frontal, left temporal and left parietal lobes also bilateral medial parts of the thalamus, and also, increased T1 signal intensity compatible with laminar necrosis was detected in the cortex. In T2 sequences, increased signal intenisty was observed at the head of the left caudate nucleus and the superior part of the lentiform nucleus, bilateral posterior frontal and parietal, and left temporal deep white matter (Figure 1,2,3).

Discussion: In most cases, treatment is started based on possible MRI findings before PCR results are obtained (2,3). In literature , have been reported for white matter (1), brain stem (4), thalamus and basal ganglia (5). When there is no lesion in commonly involved regions of the brain, clinicians may have the tendency to ignore the diagnosis of HSV. We find it valuable to present this case to point out that HSV-1 may involve different regions of the brain other than classical involvements, so HSV should be kept in mind as well in such cases.