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The International Child Neurology Association (ICNA) invites "letter of intent" from interested parties to enter the bidding to host the International Child Neurology Congress in 2024. 

Bidders are invited to send a "letter of intent" (not more than a short paragraph from the main coordinator or organizing scientific society (not the...

The International Child Neurology Association (ICNA) invites "letter of intent" from interested parties to enter the bidding to host the International Child Neurology Congress in 2024. 

Bidders are invited to send a "letter of intent" (not more than a short paragraph from the main coordinator or organizing scientific society (not the conference organising team) to the ICNA office with the Secretary of ICNA (secgen.icna@gmail.com) in copied in.

  1.   02 February 2020
  2.   News

 Johnen A and colleagues from University of Münster, Germany in a recently published study in the European Journal of Paediatric Neurology suggests that early initiation of highly effective escalation therapies in pediatric patients with multiple sclerosis (MS) is associated with reduced cognitive impairment (CI)...

 Johnen A and colleagues from University of Münster, Germany in a recently published study in the European Journal of Paediatric Neurology suggests that early initiation of highly effective escalation therapies in pediatric patients with multiple sclerosis (MS) is associated with reduced cognitive impairment (CI) and may prevent cognitive decline in these patients.

They did a cohort study of 19 patients from a single center in Germany with therapy-naive or ß-interferon-treated juvenile MS (mean age, 15.05 years). The study participants completed a comprehensive neuropsychological assessment at the time of initial presentation and again at a mean follow-up period of 2.5 years. Physical disability was also assessed, along with neurological examination and magnetic resonance imaging (MRI).

At baseline, 47% (n=9) of patients were considered impaired in ≥1 cognitive test (z-score <−1.645 compared with age-adjusted normative data). The highest impairment frequency was found in domains for processing speed, as well as attention and executive function. At follow-up a higher impairment frequency was prominent in those patients whose therapy had not been escalated (N = 13, 69% impaired in at least one test), while cognition was preserved or ameliorated in patients whose treatment had been escalated to highly effective drugs (N = 6, 0% impaired) during the observational period.

These group differences at follow-up were not attributable to differences regarding demographics, MRI metrics or cognitive performance at baseline.
Johnen A, Elpers C, Riepl E, Landmeyer NC, Krämer J, Polzer P et al. (2019) Early effective treatment may protect from cognitive decline in paediatric multiple sclerosis. Eur J Paediatr Neurol 23 (6):783-791. DOI: 10.1016/j.ejpn.2019.08.007 PMID: 31540711

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  1.   03 December 2019
  2.   News

 In a fascinating new study published in Cell Reports investigators from California Institute of Technology, Pasadena, California quantifying intrinsic functional connectivity in six individuals who underwent hemispherectomy, in childhood. Studies of temporal correlations of blood-oxygenation-level-dependent signal (BOLD) as indirect measures...

 In a fascinating new study published in Cell Reports investigators from California Institute of Technology, Pasadena, California quantifying intrinsic functional connectivity in six individuals who underwent hemispherectomy, in childhood. Studies of temporal correlations of blood-oxygenation-level-dependent signal (BOLD) as indirect measures of intrinsic functional connectivity with resting-state fMRI have suggested that a relatively small set of resting-state functional brain networks underlie cognition and behaviour. It has been known that despite profoundly atypical anatomy some individuals have been able to retain relatively intact cognitive abilities. However it has not been explained whether this compensation is due to a reorganisation of functional networks or whether the integrity of cognitive function is always dependent on basic resting-state networks.For this study hemispherectomy subjects and healthy controls were scanned with identical parameters on the same scanner and compared to a large normative sample (n = 1,482). 

The researchers found that both hemispherectomy subjects and controls showed strong and equivalent intrahemispheric connectivity between brain regions typically assigned to the same functional network.For most of the hemispherectomy subjects the connectivity between different parts of different networks was markedly increased across all networks. The researchers hypothesize that a shared set of functional networks underlie cognition and that between-network interactions may characterize functional reorganization in hemispherectomy. Although there are several studies looking at the compensations in brain function following hemispherectomies, this is the first study to investigate resting-state functional networks across the entire hemisphere in individuals with hemispherectomy.

Hemispherectomies are performed in children with severe and intractable seizure disorder. Hemispherectomy is typically performed on children with Rasmussen's syndrome and on children have had strokes either perinatally or in early childhood and who have had intractable seizures often limited to one side of the brain. The study has provided fascinating new evidence on the reorganization of neural networks which results in compensated cognition following hemispherectomy and opens exciting prospects for further applications for resting-state fMRI studies on task-based functional localization.

Citation:

Kliemann D, Adolphs R, Tyszka JM, Fischl B, Yeo BTT, Nair R et al. (2019) Intrinsic Functional Connectivity of the Brain in Adults with a Single Cerebral Hemisphere.Cell Rep 29 (8):2398-2407.e4. DOI: 10.1016/j.celrep.2019.10.067 PMID: 31747608.



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  1.   03 December 2019
  2.   News

On behalf of the International Child Neurology Association, it is my great pleasure to welcome you to the 16th International Child Neurology Congress being held in San Diego, USA October 19-23rd 2020 in collaboration the Child Neurology Society. Our congress theme is "Sharing Knowledge, Sowing Friendships, Spreading Hope". The ICNCs have...

On behalf of the International Child Neurology Association, it is my great pleasure to welcome you to the 16th International Child Neurology Congress being held in San Diego, USA October 19-23rd 2020 in collaboration the Child Neurology Society. Our congress theme is "Sharing Knowledge, Sowing Friendships, Spreading Hope". The ICNCs have truly set the stage as the key forum which provides the very latest and most relevant updates on child neurologic disorders from a global perspective. Speakers from across the six major geographic regions will present at the congress. The scientific program will feature internationally recognized experts including themes of "Developmental and Epileptic Encephalopathies: What we know and what we do not know" (Nicola Specchio / Pritchard award); "Update in Pediatric Neurometabolic Disorders 2020: cerebral folate deficiency and disorders of polyamine metabolism" (Lance Rodan / Linda de Meirleir Neurometabolic award); "Burden of Neurological Conditions in the World's Children" (Charles Newton / Frank Ford Award) and "Dietary therapies for epilepsy in low resource settings: Challenges and successes" (Suvasini Sharma/ Shiela Wallace Award).

We are keen to hear from members of the ICNA and CNS community and encourage you to submit your proposals for symposium sessions, platform and poster presentations. Following the successful framework of previous congresses the globally representative scientific committee, chaired by Prof Jonathan Mink, will select the most innovative proposals to ensure a rich and diverse program which guarantees that all delegates will leave inspired and with knowledge gained.

There will be opportunity for the newly established Council of the Future Leaders of ICNA comprised of outstanding, regionally nominated senior child neurology residents, fellows and junior faculty to meet and discuss strategy, as well as how the ICNA can support junior child neurologists. In-line with previous congresses we will offer a number of bursaries for attendees from low and low middle income countries. Based on popular demand there will be a strong educational program inclusive of master classes and teaching courses. There will also be an opportunity for the meeting of different child neurology subspecialty special interest groups.

The networking opportunities building international collaborations is a key theme for the ICNA and the 2020ICNC-CNS congress will be an ideal opportunity to pursue this. The congress promotes connecting clinicians involved in the phenotyping of unique clinical populations afflicted with specific neurological diseases with researchers in state-of- the-art research laboratories. 

Please join us for a scientifically stimulating ICNC2020 program in an atmosphere of warm collegiality at the beautiful coastal destination of San Diego, complete with access to stunning beaches, hikes along sandstone cliffs of the Torrey Pines State Natural Reserve and exploring the cultural hub at Balboa Park with its many museums, theatres and gardens.

We look forward to meeting new colleagues and engaging with old friends there.

Obo of the ICNA board
Jo Wilmshurst
President of the ICNA

Any child neurologist feeling burnt out or harboring doubts about the future of our profession while flying in to Charlotte for last month's CNS Annual Meeting almost certainly flew home with a wholly revised, reassuring and reinvigorated sense that the future is very bright. In my privileged position as incoming President, I had the chance to learn about the 50+ early career physician-researchers attending the NIH-funded CNCDP (Child Neurologist Career Development Program) Retreat. And as co-director with Renée Shellhaas and Elaine Wirrell of the 4th Annual John M. "Jack" Pellock Resident Seminar on Epilepsy, I had the pleasure of spending two days with the 80 PGY5 residents nominated by their training program to attend the course. I also had the opportunity, along with Renée and Elaine, to review CVs submitted by 17 of those residents applying for two CNS-CNF-AES Pellock Fellowships. Together, we exhaled a collective "WOW!" We have some upcoming superstars in our midst, and lots of shared talent and enthusiasm. What a refreshing feeling!

The meeting was a huge success across the board as the first wave of post-meeting surveys and comments submitted from among the record-setting 1400+ attendees amply attests. My thanks to my predecessor Jonathan Mink, and Scientific Selection and Program Planning Committee Chair, Erika Augustine, both from the University of Rochester, for their incredible work putting this together. From the Neurobiology of Disease in Children (NDC) symposium on brain tumors, to the Presidential symposium on Genetic Heterogeneity and Phenotype Pleiotropy, to the full slate of outstanding symposia, breakfast seminars, meet the expert sessions, and Special Interest Group (SIG) meetings, the excitement was palpable. The Sachs (Scott Pomeroy, Boston), Dodge (Louis Dang, Ann Arbor), and Hower (Jim Bale, Salt Lake City) Award lectures were brilliant. The same was true for the well-attended poster sessions and exhibits. And, if you caught the jazz band performance during the Gala Closing Reception on Friday, you may have noticed that I recruited the top drawer rhythm section at the University of North Carolina in Charlotte to, fittingly, close the week out in style!

Be sure to mark your calendars now to be in sunny San Diego next fall, October 19-23, 2020 for the much-anticipated joint meeting with our International Child Neurology Association colleagues. The last (and only) time the CNS hosted a joint meeting with ICNA was in San Francisco in 1994. Attendance for that meeting was just over 1000; next year's joint meeting is expected to draw 2500 attendees. The meeting will run 4-1/2 days (one extra day) and will include 28 two-hour symposia, 8 award/plenary lectures, multiple "Meet the Expert," breakfast and junior member seminars, more than a dozen joint CNS-ICNA Special Interest Group meetings, 120+ exhibits, 700+ posters, and wall-to-wall networking possibilities in the sparkling new Marriott Marquis conference center located alongside the San Diego marina. You won't want to miss this meeting!

The November 15 deadline for submitting symposia proposals is fast approaching, followed immediately by a two-month abstract submission period (November 15 – January 15). A super-star line-up of award/plenary lecturers has already been drawn up by ICNA and CNS awards committees. These will be announced in early December. Notification of symposia proposals accepted for presentation will be issued in late December with a preliminary program announced in early January. This involves a tremendous amount of time and effort on the part of both CNS and ICNA members volunteering their time to serve on the program planning committees. Special thanks is due now and through the coming year to Carl Stafstrom from Johns Hopkins, and Erika Augustine for agreeing to co-chair the 2020 CNS Scientific Program Planning Committee in concert with the ICNA Scientific Program Planning Committee chaired by Jon Mink.

Sincerely,

Phillip L. Pearl, MD
President, Child Neurology Society

  1.   23 November 2019
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  1.   23 November 2019
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