[2018 Round-up] Treatment of epilepsy in light of the most recent advances

The long-term effects of antiepileptic drugs are still disputed. Although the response to the available antiepileptic drugs is favourable in up to 80% of cases, seizure control in the long term is still ill-defined. This issue was addressed by a clinic-based cohort study on treatment outcomes in 1795 patients with newly diagnosed epilepsy, followed up for up to 30 years.1 The study reported that 820 (46%) patients remained seizure-free for 1 year or longer with the first antiepileptic drug. Only 324 (18%) additional patients became seizure-free after change in treatment, despite an increasing use of second-generation and third-generation antiepileptic drugs.

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