In a study published in Current Biology today, researchers from King's College London uncovers the precise mechanisms by which autophagy leads to cell death. The study used a mouse model for the polyglutamine disease dentatorubral-pallidoluysian atrophy (DRPLA), progressive acquirement of an ataxic phenotype linked to severe cerebellar cellular pathology, characterized by nuclear degeneration through nucleophagy-based LaminB1 degradation and excretion. DRPLA is caused by ...
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