Handbook of Pediatric Electroencephalography by Veena Kander now on ICNApedia VLE

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Seizure detection using multiple biosignals more accurate than detection by heart rate changes alone

According to data presented at the 2015 American Epilepsy Society Annual Meeting in Philadelphia seizure detection using multiple extracerebral biosignals specifically [HR], [SpO2] and electrodermal activity [EDA] results in improved accuracy compared with heart rate alone. Using 2 commercially available wrist-worn devices, Cogan and colleagues gathered HR, arterial oxygenation (SpO2), and EDA data from 20 patients electively admitted to an epilepsy-monitoring unit. Of these patients, 11 provided HR, SpO2, and EDA data on 24 seizures during 355 hours of data collection. In all 24 of the captured seizures HR increased by 15% or more. In 20 of these seizures, an SpO2...
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Seizure detection device sensitivity comparable to video EEG

Data presented at the 2015 American Epilepsy Society Annual Meeting in Philadelphia shows that sensitivity of the Brain Sentinel™ system for detection of GTCS is comparable to epileptologists reviewing vEEG recordings. The system, which collects continuous surface electromyography (sEMG) and audio data via a device strapped to the bicep, is currently under review by the FDA. The device algorithm continuously compares recorded surface EMG signals to the baseline sample of muscle activity. (GTC seizures are signalled with sustained activation of multiple frequency bands [30 to 40 Hz, 130 to 240 Hz, 300 to 400 Hz] of EMG activity.) Quantitative review of...
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Cannabidiol effective in treatment of intractable epilepsy

Results from open-label Expanded Access treatment programs from 16 centres presented at the 2015 American Epilepsy Society Annual Meeting in Philadelphia, show that Epidiolex, a pharmaceutical-grade, purified form of cannabidiol, is generally well-tolerated and is a promising treatment for treatment-resistant epilepsies. Epidiolex, manufactured by GW Pharma, is a highly-standardized, plant-derived form of cannabidiol (CBD), the most abundant non-psychoactive cannabinoid derived from the cannabis plant. Anecdotal reports and animal studies in multiple species and models have shown anticonvulsant efficacy for cannabidiol in intractable epilepsies including Dravet syndrome and Lennox-Gastaut syndrome. For the current study by Devinsky et al, children and young adults...
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Target resequencing of epilepsy candidate genes helps expand phenotype

In data was presented at the 2015 American Epilepsy Society Annual Meeting, Candace Myers, PhD, of the University of Washington, and colleagues have shown that targeted high throughput resequencing of genes in which a de novo mutation was previously been identified can help expand the phenotypic spectrum associated with these genes. They sought to expand on their previous study where they identified 329 de novo mutations in 305 genes when 264 trios (affected child and unaffected parents).For their current study the researchers performed targeted capture and high-throughput resequencing of 27 genes in which a de novo mutation was identified in one...
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Role of circadian genes in the pathogenesis of Paediatric Focal Epilepsy

According to research presented at the 2015 American Epilepsy Society annual meeting in Philadelphia, dysfunction of brain circuits in pediatric patients with focal epilepsy results from a significant reduction in Circadian Locomotor Output Cycles Kaput (Clock) expression. The researchers including Judy Liu MD PhD and her colleagues at the Children’s National Medical Center in Washington studied patients with focal epilepsy enrolled under their epilepsy surgery program. They used high-resolution 3t magnetic resonance imaging to determine epileptogenic foci and collected samples directly from the operating room for transcriptome analysis performed by microarray using Illumina® Gene Expression Bead Chip Array technology. Studies in...
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