Handbook of Pediatric Electroencephalography by Veena Kander now on ICNApedia VLE

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High folate and vitamin B12 levels and autism risk

Researchers from Johns Hopkins Bloomberg School of Public Health have found that if a new mother has a very high level of folate right after giving birth – more than four times what is considered adequate – the risk that her child will develop an autism spectrum disorder doubles. Very high vitamin B12 levels in new moms are also potentially harmful, tripling the risk that her offspring will develop an autism spectrum disorder. If both levels are extremely high, the risk that a child develops the disorder increases 17.6 times. Folate, a B vitamin, is found naturally in fruits and vegetables, while the...
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EpilepsyDiagnosis.Org – a novel online diagnostic manual of the epilepsies

Background Although there is much information on the internet about epilepsy and seizures, ther...
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CDC Guidelines for Infants Exposed to Zika Virus

The U.S Centers for Disease Control have published interim guidelines evaluation and testing of infants born to mothers who may have been exposed to Zika virus during pregnancy. The guidelines suggest that pediatric health providers should work together with obstetric providers in order to identify infants whose mothers may have been exposed to Zika virus during pregnancy and fetal ultrasounds should be reviewed and maternal testing for Zika virus should be considered. Infants with microcephaly or intracranial calcifications born to women who traveled to or resided in an area with Zika virus transmission during pregnancy, and infants born to mothers with...
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Leukemia drug dasatinib shows promise for treating duchenne muscular dystrophy

Professor Winder's group at the University of Sheffield investigating the cancer drug, dasatinib, a potent and specific Src tyrosine kinase inhibitor has shown that it decreases the levels of β-dystroglycan phosphorylation on tyrosine and to increase the relative levels of non-phosphorylated β-dystroglycan in dystrophic sapje zebrafish. Tyrosine phosphorylation and degradation of β-dystroglycan is a key event in the aetiology of Duchenne muscular dystrophy. Dasatinib treatment resulted in the improved physical appearance of the sapje zebrafish musculature and increased swimming ability as measured by both duration and distance of swimming of dasatinib-treated fish compared with control animals. These findings show great promise...
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CRISPR gene editing successfully treats Duchenne Muscular Dystrophy in Mice

Researchers have shown that they were able to improve muscle function in  Duchenne Muscular Dystrophy mice using in vivo gene editing techniques. Duchenne muscular dystrophy (DMD) affects about 1 out of 5000 male births and caused by mutations in the dystrophin gene. Though DMD has been a target for gene therapy for a long time, progress has been very slow and attempts unsuccessful.The dystrophin gene has 79 sections, or exons, but can retain reasonable function even if a few exons in the middle are lost. Dystrophin works as long as its two ends are intact as in the case of Becker...
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4th European Stroke Organisation Conference (ESOC 2018)