MRI algorithm to predict which babies at high risk of developing autism

Joe Piven, MD

Using magnetic resonance imaging (MRI) in infants with older siblings with autism, researchers from around the country were able to correctly predict 80 percent of those infants who would later meet criteria for autism at two years of age. The study, published today in Nature, is the first to show it is possible to identify which infants – among those with older siblings with autism – will be diagnosed with autism at 24 months of age. This first-of-its-kind study used MRIs to image the brai...
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Role for GABA in accelerating brain activity - new mechanism for epilepsy

Following a prolonged epileptic seizures  neural connections of the brain may be rewired in an incorrect way. This may result in seizures that are difficult to control with medication. Mechanisms underlying this phenomenon are not entirely known, which makes current therapies ineffective in some patients. In a study, published in the Annals of Neurology, researchers at the  Neuroscience Center of the University of Helsinki have shown a role for gamma-aminobutyric acid (GABA),...
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Nodding syndrome caused by response to parasitic protein

​ Researchers have linked Nodding syndrome, a devastating form of pediatric epilepsy found in specific areas of east Africa, to a parasitic worm that can cause river blindness. The study, published in Science Translational Medicine, suggests that the mysterious neurological disease may be caused by an autoimmune response to the parasitic proteins. "This study identifies a cause of Nodding syndrome. But more broadly, these findings provide a novel perspective on epilepsy and suggest that som...
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New drug targeting histamine for cataplexy in narcolepsy

A randomized, double-blinded trial has shown that pitolisant, a drug that targets a specific histamine receptor, can reduce cataplexy, a very disabling symptom of narcolepsy. Cataplexy is a sudden and uncontrollable muscle weakness or paralysis that comes on during the day and is often triggered by a strong emotion, such as excitement or laughter. The loss of muscle tone in cataplexy occurs because of the inability to regulate sleep and awake states -- meaning that elements o...
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Welcome to the 15th International Child Neurology Congress

On behalf of the International Child Neurology Association, it is my great pleasure to welcome you to the 15 th International Child Neurology Congress being held in Mumbai, India in Nov. 2018. Our congress theme is 'Protecting the developing brain'. We aim to provide an overview of Childhood Neurological Disorders from a Global Perspective with strong representation from all six major geographic regions. The scientific program will feature internationally recognized experts who will provide the latest advances within different subspecialties of child neurology, including two tribute lectures to honour the lifetime contributions of two remarkable pioneers of Child Neurology, Dr. Yukio Fukuyama and Dr. Masaya Segawa. This will be combined with a strong educational program through breakfast teaching courses, workshops, afternoon tea symposia with algorithmic approaches and instructive case presentations and evening master classes.

Several exciting ICNA initiatives will also be featured. There will be a symposium dedicated to a review of the integral components of solid clinical research methodology and rigorous study design including the needed framework for prospective randomized, double-blind, placebo-controlled trials. The ICNC2018 

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