The International Child Neurology Association
ICNA

Professor Lieven Lagae awarded the 2nd Aicardi Award Lecture 2019


The ICNA congratulates Professor Lieven Lage on being awarded the Aicardi Lecture 2019 for his contributions to child neurology. The biennial Aicardi Award established by the European Paediatric Neurology Society (EPNS) in partnership with MacKeith Press  recognises a respected and admired doctor who has attained major achievements in child neurology.  Recipients of the award must practice in Europe using the countries in the WHO European region. The 2029 award presentation and lecture took at the EPNS Congress in Athens on 17 September 2019. Professor Lagae gave the Aicardi Lecture on the " Miss Understanding is the Greek Goddess of Clinical Research" where he talked about...
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ICNA

Global Burden of Disease Fellowship Programme

Applications are invited from interested Project Supervisors for Seed Grant Funding under the Global Burden of Disease ( GBOD ) Research Trainee Fellowship program a new initiative of the International Child Neurology Association (ICNA). The Award The award consists of $ 2,000 for room and board for ~ 2-3 months plus up to $ 2,000 for roundtrip airfare. Timeline The deadline date for receipt of proposals on open competition from project supervisors is August 1. The Scoring and Selection of Grants fulfilling Criteria by Research Task Force Committee (10 point scoring system) will be completed by September 1 and results announced on ICNApedia. The deadline for...
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ICNA

First model of mitochondrial epilepsy developed


Researchers from Trinity College Dublin publishing in BRAIN describes for the first time a model of mitochondrial epilepsy. Mitochondrial disease is one of the most common forms of genetic diseases, affecting one in 9,000 births in Ireland with debilitating consequences. A quarter of patients with mitochondrial disease have epilepsy which is often severe and resistant towards conventional antiepileptic drugs. Currently no animal models are available to provide a mechanistic understanding of the condition. The current study has thrown light at the important role that astrocytes play in driving seizure generation in mitochondrial epilepsy. They recreated a novel brain slice model by the application of...
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ICNA

US FDA approves world's most expensive drug Zolgensma one-time treatment for SMA

ZOLGENSMA logo
Swiss drugmaker Novartis has received US approval for its spinal muscular atrophy gene therapy Zolgensma® (onasemnogene abeparvovec-xioiT) for the treatment of pediatric patients less than 2years of age with spinal muscular atrophy (SMA) with bi-allelic mutations in the survival motor neuron 1 (SMN1) gene). The one time treatment drug is priced at a record $2.125m. Novartis executives have defended the price, saying a one-time treatment is more valuable than expensive long-term treatments that cost several hundred thousand dollars a year. Zolgensma® is designed to address the genetic root cause of SMA by providing a functional copy of the human SMN gene to...
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ICNA

Trigger region found for absence epileptic seizures

Spike-wave discharges can be seen in the electrocorticograms (ECoGs) from the left and right somatosensory cortices (SSCs) of an Stxbp1+/? mouse. A portion of the spike-wave discharge is expanded in green below. Credit: RIKEN
Kazuhiro Yamakawa and his team at the RIKEN Center for Brain Science (CBS) in Japan has shown that absence epilepsy can be triggered by impaired communication between two brain regions: the cortex and the striatum. The researchers took STXBP1 and SCN2A genes  created mice with one normal gene and one mutated gene -- a condition called haplodeficiency, which is different from a complete knockout. They showed that Spike Wave Discharges (SWD)  can be blocked by drugs than inhibit neurons from exciting each other. The scientists injected a neuronal inhibitor into several brain regions hoping to find which ones were related to the seizures. They found...
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