Setyo Handryastuti, Achmad Rafli, Irawan Mangunatmadja, Amanda Soebadi, Yoga Devaera, Cut Nurul Hafifah, Lora Sri Nofi, Ariek Ratnawati, Suci Fitrianti

Objective: To know the efficacy of the modified Atkins diet (mAD) among children with refractory epilepsy. Method: Pre and post treatment interventional study with children diagnosed as refractory epilepsy aged 2-18 years old from April 2021-March 2022 at Dr.Cipto Mangunkusumo Tertiary General Hospital Jakarta, Indonesia. The subjects were given mAD ketogenic diet based on Indonesian Menu (as an add-on to the ongoing antiseizure drugs) who met the inclusion criteria. Main outcome measures is proportion of children who achieved seizure reduction as defined by minimal 25% cessation of seizure at 4, 12, and 24 weeks Results: Of the 41 recruited children, 28 succeed followed mAD, 13 were drop out and lost to follow up. The proportion of children with seizure reduction in first 4 weeks was 53%, 12 weeks 32%, and 24 weeks 15% (p 0,028). The proportion of children with ≥25% seizure reduction was significantly higher at first 4 and 12 weeks. The diet was well tolerated with nausea and vomiting being the most common adverse effects in children. Conclusions: The modified Atkins diet may be effective and well tolerated in Indonesian children with refractory epilepsy.
Keywords: refractory epilepsy, modified Atkins diet, children

Setyo Handryastuti
Indonesia

Achmad Rafli
Indonesia

Irawan Mangunatmadja
Indonesia

Amanda Soebadi
Indonesia

Yoga Devaera
Indonesia

Cut Nurul Hafifah
Indonesia

Lora Sri Nofi
Indonesia

Ariek Ratnawati
Indonesia

Suci Fitrianti
Indonesia