A multimodal prognostic evaluation of preterm and term infants with neonatal encephalopathy in a prospective follow-up study
Seda Kanmaz, Ozge Altun Koroglu, Mahir Tanriverdi, Demet Terek, Gul Aktan, Mehmet Yalaz, Nilgun Kultursay, Mete Akisu, Hasan Tekgul
Objective. To evaluate the neurodevelopmental outcomes in preterm and term neonates with neonatal encephalopathy. Method: Concomitant 53 newborns (preterm: 26 and term: 27) with neonatal encephalopathy who were admitted to Ege University Children’s Hospital were included in the study. The infants were prospectively followed up with a high-risk infant program in pediatric neurology outpatient. At 12 months of age, neurodevelopmental outcomes were evaluated with the Guide for Monitoring Child Development (GMCD) and the Ankara Developmental Screening Inventory (ADSI). Four groups were designed for the comparison according to their gestational ages and based on whether they had neonatal seizures or not: Group 1 (preterms with seizures; n=13), Group 2 (preterms without seizures, n=13), Group 3 (term neonates with seizures, n=13) and Group 4 (term neonates without seizures, n = 14). Results: The early mortality rate in the NICU was 24.5%. Thirty-two infants were evaluated with AGTE and GMCD tests between 9 and 12 months of age in order to determine their development and early prognosis. An adverse outcome was detected in 28% of preterm infants, and 66.7% of term infants. Among the evaluated possible 10 clinical parameters for the outcome, the magnitude of brain pathology on neuroimaging and the grading of EEG background abnormalities (r-cEEG and aEEG) are significant clinical parameters for adverse outcome in infants with neonatal encephalopathy (Table 1). Conclusion. This study provides the spectrum of neurodevelopmental outcome characteristics and prognostic parameters for adverse outcomes in preterm and term infants with neonatal encephalopathy in an etiologically well-defined cohort.
Keywords: neonatal encephalopathy, overall outcome, neurodevelopmental outcome, neonatal seizures, aEEG
Seda Kanmaz
Ege University Medical Faculty
Turkey
Ozge Altun Koroglu
Ege University Medical Faculty
Turkey
Mahir Tanriverdi
Ege University Medical Faculty
Turkey
Demet Terek
Ege University Medical Faculty
Turkey
Gul Aktan
Ege University Medical Faculty
Turkey
Mehmet Yalaz
Ege University Medical Faculty
Turkey
Nilgun Kultursay
Ege University Medical Faculty
Turkey
Mete Akisu
Ege University Medical Faculty
Turkey
Hasan Tekgul
Ege University Medical Faculty
Turkey
Objective. To evaluate the neurodevelopmental outcomes in preterm and term neonates with neonatal encephalopathy. Method: Concomitant 53 newborns (preterm: 26 and term: 27) with neonatal encephalopathy who were admitted to Ege University Children’s Hospital were included in the study. The infants were prospectively followed up with a high-risk infant program in pediatric neurology outpatient. At 12 months of age, neurodevelopmental outcomes were evaluated with the Guide for Monitoring Child Development (GMCD) and the Ankara Developmental Screening Inventory (ADSI). Four groups were designed for the comparison according to their gestational ages and based on whether they had neonatal seizures or not: Group 1 (preterms with seizures; n=13), Group 2 (preterms without seizures, n=13), Group 3 (term neonates with seizures, n=13) and Group 4 (term neonates without seizures, n = 14). Results: The early mortality rate in the NICU was 24.5%. Thirty-two infants were evaluated with AGTE and GMCD tests between 9 and 12 months of age in order to determine their development and early prognosis. An adverse outcome was detected in 28% of preterm infants, and 66.7% of term infants. Among the evaluated possible 10 clinical parameters for the outcome, the magnitude of brain pathology on neuroimaging and the grading of EEG background abnormalities (r-cEEG and aEEG) are significant clinical parameters for adverse outcome in infants with neonatal encephalopathy (Table 1). Conclusion. This study provides the spectrum of neurodevelopmental outcome characteristics and prognostic parameters for adverse outcomes in preterm and term infants with neonatal encephalopathy in an etiologically well-defined cohort.
Keywords: neonatal encephalopathy, overall outcome, neurodevelopmental outcome, neonatal seizures, aEEG
Seda Kanmaz
Ege University Medical Faculty
Turkey
Ozge Altun Koroglu
Ege University Medical Faculty
Turkey
Mahir Tanriverdi
Ege University Medical Faculty
Turkey
Demet Terek
Ege University Medical Faculty
Turkey
Gul Aktan
Ege University Medical Faculty
Turkey
Mehmet Yalaz
Ege University Medical Faculty
Turkey
Nilgun Kultursay
Ege University Medical Faculty
Turkey
Mete Akisu
Ege University Medical Faculty
Turkey
Hasan Tekgul
Ege University Medical Faculty
Turkey
Seda Kanmaz
Ege University Medical Faculty Turkey
Ege University Medical Faculty Turkey