Introduction: There is paucity of data on the electroclinical spectrum of epilepsy in infants and young children and the use of ILAE 2022 diagnostic system. This study was planned to study clinico-etiological profile & electro-clinical spectrum of epilepsy in children up to 2 years of age as per ILAE 2022 diagnostic system. Methods: This was a hospital based cross-sectional study. Children up to 2 years diagnosed with epilepsy were enrolled. Details of neonatal period, age of onset of seizures, seizure type, EEG, MRI findings, genetic testing and co-morbidities were noted. Epilepsy syndrome diagnosis was done as per ILAE 2022 diagnostic scheme. Results: 72 children [55 (76.38%) boys & 17 (23.6%) girls] were enrolled. Mean age of onset was 4.4 months. Infantile epileptic spasm syndrome was the most common epileptic syndrome, in 50 children (69.4%). 15 (20.8%) children had non-syndromic focal epilepsy. 4 (5.5%) had early infantile developmental and epileptic encephalopathy. Perinatal asphyxia was the most common etiology (41.66%), followed by genetic causes (18.05%), and neonatal hypoglycemic brain injury (13.88%). 58 children (80.55%) had global developmental delay, 31 children (43.05%) had cerebral palsy, 24 children (33.33%) had vision impairment, 21 children (29.16%) had microcephaly as co-morbidities. Conclusion: Infantile epileptic spasm syndrome was the most common epilepsy syndrome noted in this age group. Neurodevelopmental co-morbidities such as global developmental delay and cerebral palsy were common, indicating the need for screening and multidisciplinary care. Disclosure: Lady Hardinge Ethical Committee

Ganesh Kumar R
Kalawati Saran Children's Hospital
India

Suvasini Sharma
Kalawati Saran Children's Hospital
India

Sharmila Mukherjee
Kalawati Saran Children's Hospital
India