Title: Epileptic Seizures in Acute Leukemia in Children: A Clinical Analysis Authors: Sh. Sh. Shamansurov, D. F. Mirzaeva Objective: The aim was to study epileptic seizures in children with acute leukemia during polychemotherapy. Methods: From January to October 2023, we examined children diagnosed with "acute leukemia". Results: 84 children diagnosed with "Acute Leukemia" were examined. Among them, 26 (30.9%) experienced epileptic seizures during the therapy. Out of 26 children, 8 (30.7%) were in the high-risk group, while the remaining children were in the low-risk group. Epileptic seizures in these children were observed at the stage of consolidation phase 3. In 5 (19.2%) children, epileptic seizures were observed at the onset of the disease, unrelated to chemotherapy. 7 (26.9%) children had the aforementioned complaints during the remission induction stage, and seizures were observed in 4 (15.3%) children during the consolidation phase 1. The semiology of the seizures was diverse: complex focal epileptic seizures were most commonly observed in 14 (53.8%) children with acute leukemia, generalized seizures were noted in 30.7% of cases - in 8 children, simple focal seizures in 1 child, and complex focal seizures evolving into bilateral tonic-clonic seizures were registered in 3 (11.5%) children. Half of the children had structurally related epileptic seizures, observed as part of posterior reversible encephalopathy syndrome and methotrexate leukoencephalopathy. Conclusion: Epileptic seizures are one of the most common neurological complications in children with acute leukemia. Diagnostic investigations such as brain MRI and EEG can be helpful for the appropriate management of these patients.

Shaanvar Shamansurov
Center for the development of professional qualification of medical workers
Uzbekistan

Dilnoza Mirzaeva
Center for the development of professional qualification of medical workers
Uzbekistan