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Clobazam was the first 1,5-benzodiazepine and was designed to have a chemical structure with a different pharmacological profile from that of the 1,4-benzodiazepines.
 
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Wiki 3786   0
Clonazepam is a 1,4-benzodiazepine.
 
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Wiki 10192   0
Comparitive genomic hybridization (CGH) or Chromosomal microarray analysis(CMA) is a modern cytogenetic technique for analyzing variations in DNA copy-number. Alteration in DNA copy number is one of the many ways in which modification of gene expression and function occurs. The technology was initially used for studying chromosomal imbalances in solid tumours.
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{tabulizer:include style[gr.alterora.basic.css] id[tab_OPk9CyOneX]} EEG pattern in common epileptic seizures Seizure type Semiology Ictal EEG Ictal EMG (both deltoids) Comments ...
 
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The International League Against Epilepsy (ILAE) Commission on Classification and Terminology has revised concepts, terminology, and approaches for classifying seizures and forms of epilepsy.
 
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{tabulizer:include style[gr.alterora.elemental_2_grey.css] id[tab_rKRBVS3i1M]} Nonspecific combinations of epileptic and non-epileptic phenomena Condition Epileptic component Non-epileptic component Investigations ...
 
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Eslicarbazepine acetate [(S)-(--)-10-acetoxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide] is a prodrug of eslicarbazepine (S-9-(-)-10-acetoxy-10,11-dihydro-5H-dibenz/b,f/azepine-5-carboxamide) and shares with carbamazepine and oxcarbazepine the dibenzazepine nucleus bearing the 5-carboxamide substitute, but is structurally different at the 10,11-position. Eslicarbazepine acetate is the latest AED to be licensed in Europe (April 2009) with the brand names Exalief and Zebinix (it will trade in USA as Stedesa).
 
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Ethosuximide (α-ethyl-α-methyl-succinimide) is the main survivor of the succinimides. It was first introduced in clinical practice in the early 1950s for the treatment of ‘petit mal’.
 
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Wiki 4478   0
In 1993, felbamate, a 2-phenyl-1,3-propanediol dicarbamate, became the first AED since 1978 to be approved by the FDA with the brand name Felbatol. Unlike its dicarbamate analog meprobamate, it has minimal anxiolytic and sedative-hypnotic effects in therapeutic doses.
 
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Fever induced refractory epileptic encephalopathy in school age children (FIRES) is a devastating condition which follows a prolonged refractory status epilepticus (SE) triggered by fever of unknown cause. The intractable perisylvian status epilepticus might persist for more than a month and results in severe cognitive impairment.
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