<![CDATA[Leucodystrophy]]> https://www.icnapedia.org/ https://www.icnapedia.org/neuroimages/9796 <![CDATA[Vanishing White Matter Disease (6 yrs male)]]> https://www.icnapedia.org/neuroimages/9796 ]]> Fri, 24 Nov 2017 21:46:16 +0000 9796 2017-11-24 https://www.icnapedia.org/media/reviews/photos/original/ca/f8/9d/vanishing-white-matter-85-1511567998.png         var folders = ["../radviewer/9796/t2/", "../radviewer/9796/flair/", "../radviewer/9796/dwi/"];         var title = ['AXIAL T2', 'CORONAL FLAIR', 'DWI']; ]]> There is marked cerebral white matter volume loss, with widening of the sulci throughout, and enlargement of the lateral and third ventricles. The white matter returns abnormal high T2 signal/ low FLAIR signal suggesting the white matter has been almost completely replaced by near CSF intensity fluid. Appearances are typical of vanishing white matter disease. Cerebellar volume is relatively well preserved. There appears to be symmetrical restricted diffusion within the subthalamic nuclei and tectum of the midbrain. This may just represent relative sparing of these tissues.]]> https://www.icnapedia.org/neuroimages/8791 <![CDATA[Alexander Disease (male, 4 yrs)]]> https://www.icnapedia.org/neuroimages/8791 ]]> Sun, 22 Jan 2017 19:16:18 +0000 8791 2017-01-22 https://www.icnapedia.org/media/reviews/photos/original/1f/70/ce/2017-01-22-19-33-47-97-1485114073.jpg         var folders = ["../radviewer/8791/t2_tra/", "../radviewer/8791/t2w_tse/", "../radviewer/8791/t1_sag/", "../radviewer/8791/dwi/"];         var title = ['AXIAL T2', 'T2w TSE', 'SAG T1', 'DWI']; ]]> Extensive leukodystrophy changes with a predominance in the frontal regions but also extending towards the parietal lobes and external capsules in keeping with Alexander's disease. These areas demonstrate free diffusivity. There is evidence of an optic pathway glioma. . A second lesion is demonstrated in the dorsal medulla. This is slightly exophytic. This lesion is more pronounced on the sagittal T1 weighted imaging but is probably of very similar size on the axial T2 weighted imaging. There is no hydrocephalus.]]>