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Prof Haluk Topaloğlu
Prof Haluk Topaloğlu
1069 0
Hatice Bektaşa, Haluk Topaloğlua Department of Paediatric Neurology, Hacettepe Children's Hospital, Ankara, 06100, Turkey ‘Nuclear envelopathies’ are a group of diseases resulting essentially from mutations of the genes encoding parts of the inner nuclear membrane (Emerin, MAN1, LAP2, LBR), nuclear lamina (Lamins A and C; Lamins B1) and outer nuclear membrane (Nesprins) [1) with mutations affecting Emerin, Lamins A/C and Nesprins being rarer compared with other nuclear envelope components. All three have independent disease causing properties in humans, nesprins being the third in chronology. As a historical note, the first emerin mutation was identified in...
 
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ICNA
ICNA
7000 0
Zika virus is a mosquito-borne flavivirus primarily transmitted by Aedes aegypti mosquitoes (Hayes, 2009; CDC, 2016 ) and to a lesser extent by Aedes albopictus mosquitoes. 
 
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ICNA
ICNA
4248 0
see Neonatal seizures
 
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Ashok
Ashok
14934 0
Neonatal epileptic seizures occur from birth to the end of the neonatal period.This is the most vulnerable of all the other periods of life for the development of epileptic seizures, particularly in the first 1 or 2 days from birth. Neonatal seizures differ from those of older children and adults. They may be short-lived events lasting for just a few days, but they often signify serious malfunction or damage of the immature brain, and constitute a neurological emergency that demands urgent diagnosis and management. Most neonatal seizures are acute (pro-voked, occasional, reactive) symptomatic seizures caused by an acute illness...
 
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Ashok
Ashok
7385 0
Zonisamide is a synthetic 1,2-benzisoxazole derivative (1,2-benzisoxazole-3-methanesulfonamide).
 
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Ashok
Ashok
7551 0
Vigabatrin (γ-vilyl-GABA; 4-amino-hex-5-enoic acid) was a result of a rational approach to design compounds that enhance the effect of the inhibitory neurotransmitter GABA.1-16
 
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Ashok
Ashok
13779 0
Levetiracetam is a single enantiomer, (S)-α-ethyl-2-oxo-pyrrolidine acetamide. Levetiracetam, licensed in 1999, is probably the best of all the newer AEDs1-7. It is chemically unrelated to any of the other current AEDs.
 
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Ashok
Ashok
28438 0
Lamotrigine is a 3,5-diamino-6-(2,3-dichlorophenyl)-as-triazine of the phenyltriazine class. It was first licensed for clinical practice in 1991. Lamotrigine is one of the best newer AEDs, although there are now concerns for its use in women and myoclonic epilepsies.
 
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Ashok
Ashok
23854 0
Lacosamide is a functionalized amino acid (R)-2-acetamido-N-benzyl-3-methoxypropionamide. It is one of the latest AEDs to be licensed (at the end of 2008), under the brand name Vimpat.
 
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Ashok
Ashok
6677 0
Gabapentin (1-[aminomethyl]-cyclohexaneacetic acid) first received marketing approval as an adjunctive AED for the treatment of focal epilepsies in 1993.1,2
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pleasedonate