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Evaluation of Efficacy and Tolerability of Lacosamide in Children with Drug-Resistant Epilepsy: A Multicenter Cohort Study

Objectives: We aim to evaluate the efficacy and tolerability of adjunctive lacosamide therapy in focal and generalized drug-resistant epilepsy in the pediatric population. Methods: A total of 289 patients, age at the onset of treatment ranged from 1 to 18 years, were included in the study from 14 centers. The safety, tolerability, side-effect rates, seizure frequency, and efficacy of lacosamide were evaluated. Results: The mean age of the patients included in the study was 13.52 ± 0.51 (1-24), 52.9 % (n = 153) of the patients were male (Table 1). The mean age of onset of lacosamide was 10.41 years ± 4.73 (1-18). The mean starting dose was 2.63 mg/kg/g, while the mean daily effective dose was 6.87 mg/kg/day (2.3-12) throughout the treatment period. The oral tablet form of lacosamide was found to be 88.9% (n=257) easy to use and tolerate. A significant decrease in seizure frequency was found at the 3rd month of additional lacosamide treatment [(p<0.001), Table 2]. The rate of treatment-emergent adverse events (TEAE) was 23.9% (n = 69), the most common somnolence was 10.4%(n=30, Table 3). While no change was detected in 62.6%(n:181) electroencephalographically, there was more than 50% improvement in 3.5% (n:10) and complete recovery in 3.8% (n:11). Treatment was continued in 67.8% (n=196) of the cases, and treatment was discontinued in 19.7% (n=57) because there was no change in seizure frequency. Conclusion: Our findings support that adjunctive lacosamide is effective, safe, and tolerable at doses up to 12 mg/kg/day in children with resistant epilepsy.
Keywords: Drug-resistant epilepsy, pediatric, lacosamide, efficacy

Pinar Ozkan Kart

Turkey

Esra Serdaroglu

Turkey

Nihal Yildiz

Turkey

Mehpare Sari

Turkey

Suleyman Sahin

Turkey

Gursel Sen Sen

Turkey

Pakize Karaoglu

Turkey

Pinar Gencpinar

Turkey

Betul Kilic

Turkey

Selcan Ozturk

Turkey

Elif Perihan Oncel

Turkey

Celil Yilmaz

Turkey

Arife Derda Yucel Sen

Ozlem Ersoy

Turkey

Cetin Okuyaz

Turkey

Kursat Bora Carman Carman

Turkey

Muzaffer Polat

Turkey

Ilknur Erol

Turkey

Kursad Aydin Aydin

Turkey

Hüseyin Per

Turkey

Nihal Olgac Dundar

Turkey

Aycan Unalp

Turkey

Hasan Tekgul

Turkey

Bülent Unay

Turkey

Serap Teber

Turkey

Senay Haspolat

Turkey

Ayse Serdaroglu

Turkey

Ali Cansu

Turkey

 

 


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