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Optic Neuritis in Turkish Children: A Multicenter Retrospective Study

Objective: To evaluate the demographic, clinical, laboratory, and outcome of Turkish pediatric patients with optic neuritis (ON).

Methods: A study cohort consisted of 333 patients (female: 201, male: 132) of pediatric ON from 27 centers in Turkey diagnosed between the years 2009 and 2022 were evaluated retrospectively.

Results:. The mean age was 12.65±3.90 years. Eighty-five cases (25.5%) were prepubertal. ON was unilateral in 221 (66%) patients. The most common complaints were blurred vision, vision loss, and painful eye movements. In the prepubertal period MOG antibody positivity and bilateral involvement were more frequent, and the most common final diagnoses were MOGAD and ADEM. In the postpubertal period, unilateral ON, elevated IgG index level, and OCB positivity were more frequent. Follow-up of 22.16±25.43 (0.23-132) months showed ON remained isolated in 54% of prepubertal patients while a possible or definite diagnosis of MS was established in 31.8% of postpubertal patients. Patients with bilateral involvement were more likely to have CSF pleocytosis, MOG antibody positivity, and incomplete recovery of color vision while patients with unilateral ON were older, had a higher rate of OCB positivity, and better recovery of color vision in the affected eye. The treatment modalities were pulse methylprednisolone with oral steroid tapering in 229 (69%) patients, pulse methylprednisolone only in 66 (21%), and combined treatment in 31 (9.3%) patients.

Conclusion: Our results suggest ON is commonly bilateral in prepubertal era and unilateral in postpubertal patients. Patients, particularly those of postpubertal age, need to be followed-up for further demyelinating attacks.
Keywords: Pediatric optic neuritis, multiple sclerosis, treatment, visual outcome

Meltem Cobanogulları Direk

Turkey

Seyda Besen

Turkey

İbrahim Oncel

Turkey

Ceren Gunbey

Turkey

Orhan Ozdoğan

Turkey

Leman Tekin Orgun

Turkey

Sevim Sahin

Turkey

Ali Cansu

Turkey

Nihal Yildiz

Turkey

Seda Kanmaz

Turkey

Sanem Yilmaz

Turkey

Hasan Tekgul

Turkey

Olcay Unver

Turkey

Gulten Ozturk Thomas

Turkey

Salih Basıbuyuk

Turkey

Deniz Yilmaz

Turkey

Aysegul Nese Citak Kurt

Turkey

Pembe Gultutan

Turkey

Ozlem Ozsoy

Turkey

Uluc Yis

Turkey

Semra Hız Kurul

Turkey

Serdal Gungor

Turkey

Bilge Ozgor

Turkey

Meral Karadağ

Turkey

Nihal Olgac Dundar

Turkey

Pinar Gencpinar

Turkey

Olgay Bildik

Turkey

Sibgatullah Ali Orak

Turkey

Cisil Cerci Kabur

Turkey

Bulent Kara

Turkey

Omer Karaca

Turkey

Mehmet Canpolat

Turkey

Hakan Gumus

Turkey

Huseyin Per

Turkey

Unsal Yilmaz

Turkey

Pakize Karaoglu

Turkey

Ozlem Ersoy

Turkey

Ayse Tosun

Turkey

Semra Buyukkorkmaz Ozturk

Turkey

Deniz Yuksel

Turkey

Ergin Atasoy

Turkey

Kivilcim Gucuyener

Turkey

Nazlı Balcan Karaca

Turkey

Mirac Yildirim

Turkey

Omer Bektas

Turkey

Dilek Cavusoglu

Turkey

Coskun Yarar

Turkey

Olcay Gungor

Turkey

Gulen Gul Mert

Turkey

Esra Sarıgecili

Turkey

Selvinaz Edizer

Turkey

İpek Dokurel Cetin

Turkey

Seren Aydin

Turkey

Betul Diler

Turkey

Asena Ayca Ozdemir

Turkey

İlknur Erol

Turkey

Cetin Okuyaz

Turkey

Fatma Banu Anlar

Turkey

 

 


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