Skip to main content
  Sign In   Register

ePoster Presentations Proceedings »

Long-term prognosis of neurological system in tuberous sclerosis complex with neonatal onset epilepsy

Objective We aimed to investigate the clinical manifestations and long-term neuro-systemic prognosis of neonatal-onset epilepsy related to TSC after 6years old. Methods TSC patients who developed epilepsy during neonatal period were included and followed up regularly. Cases accompanied with intrauterine hypoxia, intracranial hemorrhage, neonatal hypoxic-ischemic encephalopathy, neonatal asphyxia et al were excluded for their known long-term impact on neural system. Telephone calls were made for additional information especially on endpoint prognosis. Results There were 15 who were included in the final analysis. 86.7% (13/15) had detected abnormal signals on more than 2 regions in the brain, among them frontal lobe and parietal lobe were mostly affected (11/15 73.3% and 10/15 66.7%, respectively), followed by the frontal lobe (7/15, 46.7%) and temporal lobe (6/15, 40.0%). Calcifications were found in 80.0% (12/15) cases. In 8 cases (53.3%), abnormal origins of scalpel electroencephalogram were corresponded to imaging findings. 5 (33.3%) were onset within 7d; 12/15 (80.0%) were onset with partial seizures, 33.3% might turn to infantile spasm, 60.0% were drug refractory epilepsy. 5 undergone surgery, 80% relieved. 5 (33.3%) got seizures free at the endpoint for more than 2years. 3 (20.0%) were severe disability, 3 (20.0%) were moderate disability, 7 (46.7%) were mild disability and 2 (13.3%) were almost normal. 2 cases had autism as comorbidity and 1 of them had anxiety exhibition. Conclusions TSC with neonatal epilepsy were usually partial seizures onset; most were found with massive malformations in brain imaging. Frontal lobe and parietal lobe were mostly affected.
Keywords: Tuberous sclerosis complex (TSC); Neonate; Epilepsy; frontal-parietal lobes interaction

Yan-Wen Shen
1. Department of Pediatrics, the First Medical Centre, Chinese PLA General Hospital
China

Yong Xu

Li-Ping Zou

Meng-Na Zhang

Jing He

Wen-Jing Zhou

 

 


®2002-2021 ICNApedia