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Efficacy of teleconsultation-based rehabilitation in children with Landry Guillain Barre Syndrome: An Open Label Randomized Controlled Trial (Tele Rehab LGBS trial).

Objective: To evaluate the feasibility and efficacy of teleconsultation-based rehabilitation versus standard care in Landry Guillain barre syndrome measured with medical research council (MRC) and Hughes score. Method: A pragmatic, prospective, parallel open label randomized controlled trial. Randomization: Computer generated block randomization. Intervention: Standard care (group A) and teleconsultation-based rehabilitation (Group B). Primary outcome measured with MRC and Hughes score at 12- and 24-weeks post-discharge. Results: A total of 50 children were randomized. The mean age was 6.4±3.3 years, 29(58%) were boys. The MRC (median, IQR), and Hughes score (median, IQR) at admission in group A and B was 24(IQR (7-31) and 5 (IQR 4-5) ; and 18(IQR 9-24) and 4(IQR 4-5) (p value =0.43). In group A and B, 8 and 11 children received mechanical ventilation, and 72% were AMAN variant. At discharge, median MRC score in group A and B was 34(28-41) and 30 (25-43) (p value=0.31). At 12 weeks, 48 (96%) children were followed up; median MRC score in group A and B was 48(IQR 44-54) and 52 (IQR 46-60) (p value=0.08). Median Hughes score in group A and B was 2 IQR (1-3) and 2 IQR (0.5-3) (p value=0.56). Compliance to tele-consultation was 96% in group B. At 24 weeks, 36(72%) children were followed up, median Hughes score in group A and B was 1 (IQR 0-2) and 0.5 (IQR 0-1.25) (p value=0.22). Conclusion: Tele-consultation-based rehabilitation was feasible with high compliance rate. MRC and Hughes score at 12 and 24 weeks were similar in both groups.
Keywords: LGBS, RCT, teleconsultation, COVID , rehabilitation

Rishitha Pravallika
Postgraduate institute of Medical Education and Research, Chandigarh
India

Renu Suthar
PGIMER
India

Amol Patil
Postgraduate institute of Medical Education and Research, Chandigarh
India

Arun Bansal
Postgraduate institute of Medical Education and Research, Chandigarh
India

Somya Saxena
Postgraduate institute of Medical Education and Research, Chandigarh
India

Lokesh Saini
PGIMER
India

 

 


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