[Comment] The cause of stroke matters for secondary preventionCardiologists do not have to obsess about the cause of acute coronary syndromes. In more than 75% of cases, the cause of the myocardial infarction is plaque rupture with local thrombus formation.1 An understanding of this mechanism drives secondary prevention—ie, antiplatelet therapy. After acute coronary syndromes, patients are initially treated with aspirin to prevent further vascular events. Findings from studies have shown the superiority of the combination of aspirin with clopidogrel to aspirin alone2 and of more potent antiplatelet drugs, such as ticagrelor3 or prasugrel.
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