Handbook of Pediatric Electroencephalography by Veena Kander now on ICNApedia VLE

Manipulating consciousness using deep brain stimulation

Studies in rats have shown that they could be either woken up or put in an unconscious state from altering their brain activity by changing the firing rates of neurons in the central thalamus. The NIH funded study was published in eLIFE. Located deep inside the brain the thalamus acts as a relay station sending neural signals from the body to the cortex. Damage to neurons in the central part of the thalamus may lead to problems with sleep, attention, and memory. Previous studies have suggested that stimulation of thalamic neurons may awaken patients who have suffered a traumatic brain injury...
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Combination of hormone therapy With Vigabatrin reduces Infantile Spasms better than hormone therapy alone

Results from the ICISS trial presented at the 69th Annual Meeting of the American Epilepsy Society (AES) suggest that a combination of hormonal therapy with vigabatrin reduces infantile spasms better than hormonal treatment alone. For this study, the ICISS trial researchers tested the hypothesis that combining prednisolone or tetracosactide with vigabatrin would result in a greater proportion of infants achieving spasm cessation compared with hormonal therapy alone. Between March 2007 and May 2014, infants with IS and a compatible EEG were enrolled in a multicenter treatment trial. Infants were randomized to receive either hormonal therapy and vigabatrin or hormonal therapy alone....
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Poverty and risk of neurological impairment

Children from low income environments appear to have a higher risk of neurological impairment than those from more economically secure circumstances, according to researchers at the National Institutes of Health and other institutions. This neurological impairment appears to be distinct from the risk of cognitive and emotional delays known to accompany early-life poverty. In most cases, the level of neurological impairment the researchers found would not be apparent to a casual observer. That level could, however, increase, the risk for childhood learning difficulties, attention deficit disorders and psychological conditions such as anxiety disorders and schizophrenia. “The size of the effect we...
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Call for Proposals 2016 for "Clinical research for new therapeutic uses of already existing molecules (repurposing) in rare diseases

E-Rare-3 Call for Proposals 2016 for "Clinical research for new therapeutic uses of already existing molecules (repurposing) in rare diseases". The eighth E-Rare joint call for funding multilateral research projects on rare diseases (JTC2016) will be open on the 7 December 2015. The following 14 countries intend to participate in this call: Austria, Canada (including Quebec), France, Germany, Hungary, Israel, Italy, Latvia, Poland, Portugal, Romania, Spain, Switzerland, Turkey. The specific objective of this call is to promote the clinical and pre-clinical proof of concept for the potential application of medicinal products in rare indications either already marketed or having achieved a...
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Abnormal cell cycle gene activity may control brain overgrowth in autistic toddlers

Further underscoring the prenatal origins of Autism Spectrum Disorder (ASD), researchers at University of California, San Diego School of Medicine describe for the first time how abnormal gene activity in cell cycle networks that are known to control brain cell production may underlie abnormal early brain growth in the disorder. The findings are published online December 14 in Molecular Systems Biology. "These findings identify common genomic defects that help explain why there are abnormal numbers of brain cells in autism, why the brain grows abnormally too large or too small in some ASD toddlers and how previously reported diverse gene mutations...
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